Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).

doi:10.1136/jmg.2006.048041

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Article

Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).

Journal of medical genetics - 1 Jun 2007

Guéant Jean-Louis, Chabi Nicodème W, Guéant-Rodriguez Rosa-Maria, Mutchinick Osvaldo M, Debard Renée, Payet Corinne, Lu Xiaohong, Villaume Christian, Bronowicki Jean-Pierre, Quadros Edward V, Sanni Ambaliou, Amouzou Emile, Xia Bing, Chen Min, Anello Guido, Bosco Paolo, Romano Corrado, Arrieta Heidy R, Sánchez Beatríz E, Romano Antonino, Herbeth Bernard, Anwar Wafaa, Namour Fares

Abstract excerpt

BACKGROUND: A 776C-->G variant (dbSNP ID: rs1801198) in the transcobalamin gene (TCN2; MIM# 275350) decreases the cellular and plasma concentration of transcobalamin and thereby influences the cellular availability of vitamin B(12). OBJECTIVE: To evaluate the worldwide prevalence of this variant and its association with homocysteine plasma level. METHODS: The study was performed in 1433 apparently healthy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17220211
DOI: 10.1136/jmg.2006.048041
PMCID: PMC2740879

Genes

TCN2
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).PMID 17220211Read ↗

The transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status.Semantic proximity Read ↗

Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.Semantic proximity Read ↗

The TCN2 776CNG polymorphism correlates with vitamin B(12) cellular delivery in healthy adult populations.Semantic proximity Read ↗

Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism.Semantic proximity Read ↗

Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children.Semantic proximity Read ↗

Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.Semantic proximity Read ↗

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Association of Transcobalamin II (TCN2) and Transcobalamin II-Receptor (TCblR) Genetic Variations With Cobalamin Deficiency Parameters in Elderly Women.Semantic proximity Read ↗

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