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Article

The TCN2 776CNG polymorphism correlates with vitamin B(12) cellular delivery in healthy adult populations.

Clinical biochemistry - 1 May 2010

Castro Rita, Barroso Madalena, Rocha Mónica, Esse Ruben, Ramos Ruben, Ravasco Paula, Rivera Isabel, de Almeida Isabel Tavares

Abstract excerpt

OBJECTIVES: Vitamin B(12), or B(12), is an essential nutrient for humans, and its deficiency is a public health problem, especially in elderly population. Around 30% of circulating total B(12) levels are attached to transcobalamin II (TCN2), being referred as holotranscobalamin (holo-TC), and representing the biologically active fraction. After cellular uptake, B(12) participates in the homocysteine (Hcy)...

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Source

Identifiers

PMID: 20144600
DOI: 10.1016/j.clinbiochem.2010.01.015

Genes

TCN2

Provenance

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