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Article

Vitamin B12 binding to mutated human transcobalamin, in-silico study of TCN2 alanine scanning and ClinVar missense mutations/SNPs.

Journal of biomolecular structure & dynamics - 1 May 2023

Abuyaman Omar, Hatmal Ma'mon M, Hijjawi Nawal, Deeb Ahmad A, Abuothman Mohammad, Taha Mutasem

Abstract excerpt

Many missense mutations/SNPs of the TCN2 gene (which yield Transcobalamin (TC)) were reported in the literature but no study is available about their effect on binding to vitamin B12(B12) at the structural level experimentally nor computationally. Predict the effect of TC missense mutations/SNPs on binding affinity to B12 and characterize their contacts to B12 at the structural level. TC-B12 binding energy...

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Source

Identifiers

PMID: 35261335
DOI: 10.1080/07391102.2022.2046638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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