Article
Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.
The Journal of nutrition - 1 Oct 2011
Riedel Bettina M, Molloy Anne M, Meyer Klaus, Fredriksen Ase, Ulvik Arve, Schneede Jørn, Nexø Ebba, Hoff Geir, Ueland Per M
Abstract excerpt
Two polymorphic variants in the gene coding for transcobalamin II (TCN2), TCN2 776C- > G and TCN2 67A- > G, may alter serum holotranscobalamin (holoTC), which in turn may affect cellular uptake of cobalamin (Cbl) and thereby Cbl status indicators. We studied the effects of TCN2 776C- > G and TCN2 67A- > G on blood concentrations of holoTC, Cbl, methylmalonic acid (MMA), and total homocysteine (tHcy) in 2411...
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