Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations.

doi:10.1093/ajcn.83.3.701

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Article

Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations.

The American journal of clinical nutrition - 1 Mar 2006

Guéant-Rodriguez Rosa-Maria, Guéant Jean-Louis, Debard Renée, Thirion Sylvie, Hong Lu Xiao, Bronowicki Jean-Pierre, Namour Farès, Chabi Nicodème W, Sanni Ambaliou, Anello Guido, Bosco Paolo, Romano Corrado, Amouzou Emile, Arrieta Heidy R, Sánchez Beatríz E, Romano Antonino, Herbeth Bernard, Guilland Jean-Claude, Mutchinick Osvaldo M

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism is heterogeneously distributed worldwide, with the highest and lowest frequencies of the T allele in Mexico and Africa, respectively, and a south-to-north gradient in Europe. Distribution of MTHFR 1298A-->C is less well known. It has been hypothesized that 677T frequency could result in part from gene-nutrient interactions. OBJECTIVE:...

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PMID: 16522920
DOI: 10.1093/ajcn.83.3.701

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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