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Article

Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism.

The American journal of clinical nutrition - 1 Jun 2005

von Castel-Dunwoody Kristina M, Kauwell Gail P A, Shelnutt Karla P, Vaughn Jaimie D, Griffin Elizabeth R, Maneval David R, Theriaque Douglas W, Bailey Lynn B

Abstract excerpt

BACKGROUND: A common genetic polymorphism [transcobalamin (TC) 776C-->G] may affect the function of transcobalamin, the protein required for vitamin B-12 cellular uptake and metabolism. Remethylation of homocysteine is dependent on the production of 5-methyltetrahydrofolate and adequate vitamin B-12 for the methionine synthase reaction. OBJECTIVES: The objectives were to assess the influence of the TC 776C--> G...

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Source

Identifiers

PMID: 15941899
DOI: 10.1093/ajcn/81.6.1436

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism.PMID 15941899Read ↗

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