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Article

Polarized and functional epithelia can form after the targeted inactivation of both mouse keratin 8 alleles.

The Journal of cell biology - 1 Dec 1991

Baribault H, Oshima R G

Abstract excerpt

We have tested the requirement of keratin intermediate filaments for the formation and function of a simple epithelium. We disrupted both alleles of the mouse keratin 8 (mK8) gene in embryonic stem cells, and subsequently analyzed the phenotype in developing embryoid bodies in suspension culture. After the inactivation of the mouse keratin 8 (mK8) gene by a targeted insertion, mK8 protein synthesis was...

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Identifiers

PMID: 1721911
DOI: 10.1083/jcb.115.6.1675
PMCID: PMC2289210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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