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Article

Generation and Characterisation of Keratin 7 (K7) Knockout Mice

31 May 2013

Abstract excerpt

Keratin 7 (K7) is a Type II member of the keratin superfamily and despite its widespread expression in different types of simple and transitional epithelia, its functional role in vivo remains elusive, in part due to the lack of any appropriate mouse models or any human diseases that are associated with KRT7 gene mutations. Using conventional gene targeting in mouse embryonic stem cells, we report here the...

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PMID: 23741325
DOI: 10.1371/journal.pone.0064404

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