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Article

Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organs.

The Journal of allergy and clinical immunology - 1 Feb 2010

Trifari Sara, Scaramuzza Samantha, Catucci Marco, Ponzoni Maurilio, Mollica Luca, Chiesa Robert, Cattaneo Federica, Lafouresse Fanny, Calvez Ronan, Vermi William, Medicina Daniela, Castiello Maria Carmina, Marangoni Francesco, Bosticardo Marita, Doglioni Claudio, Caniglia Maurizio, Aiuti Alessandro, Villa Anna, Roncarolo Maria-Grazia, Dupré Loïc

Abstract excerpt

BACKGROUND: The Wiskott-Aldrich syndrome (WAS) is a rare genetic disease characterized by thrombocytopenia, immunodeficiency, autoimmunity, and hematologic malignancies. Secondary mutations leading to re-expression of WAS protein (WASP) are relatively frequent in patients with WAS. OBJECTIVE: The...

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Source

Identifiers

PMID: 20159256
DOI: 10.1016/j.jaci.2009.11.034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159256-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organs.PMID 20159256Read ↗

Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings.Semantic proximity Read ↗

Somatic mosaicism in the Wiskott-Aldrich syndrome: molecular and functional characterization of genotypic revertants.Semantic proximity Read ↗

Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Revertant somatic mosaicism in the Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Functional correction of T cells derived from patients with the Wiskott–Aldrich syndrome (WAS) by transduction with an oncoretroviral vector encoding the WAS proteinSemantic proximity Read ↗

A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient.Semantic proximity Read ↗

Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patientsSemantic proximity Read ↗

The role of Wiskott-Aldrich Syndrome protein in activation and function of human T cellsSemantic proximity Read ↗

Wiskott–Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseasesSemantic proximity Read ↗

Retrovirus-mediated WASP gene transfer corrects Wiskott-Aldrich syndrome T-cell dysfunction.Semantic proximity Read ↗

Wiskott‐Aldrich syndrome protein: Emerging mechanisms in immunitySemantic proximity Read ↗

Clinical spectrum, pathophysiology and treatment of the Wiskott–Aldrich syndromeSemantic proximity Read ↗

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