Article
The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment--a European multicentre study.
International clinical psychopharmacology - 1 Jan 2016
Höfer Peter, Schosser Alexandra, Calati Raffaella, Serretti Alessandro, Massat Isabelle, Kocabas Neslihan A, Konstantinidis Anastasios, Mendlewicz Julien, Souery Daniel, Zohar Joseph, Juven-Wetzler Alzbeta, Montgomery Stuart, Kasper Siegfried
Abstract excerpt
So far, associations between serotonergic neurotransmission pathways and suicidality have been reported. The aim of our study was to investigate the role of genetic polymorphisms and gene-gene interactions of the 5-HTR1A and the 5-HTR2A gene on suicide risk and/or a personal history of suicide attempts. A total of 374 major depressive disorder patients, adequately treated with antidepressants for at least 4...
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