Article
PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jul 2005
Lucia Alejandro, Gómez-Gallego Félix, Barroso Inês, Rabadán Manuel, Bandrés Fernando, San Juan Alejandro F, Chicharro José L, Ekelund Ulf, Brage Soren, Earnest Conrad P, Wareham Nicholas J, Franks Paul W
Abstract excerpt
Animal and human data indicate a role for the peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PPARGC1A) gene product in the development of maximal oxygen uptake (V(O2 max)), a determinant of endurance capacity, diabetes, and early death. We tested the hypothesis that the frequency of the minor Ser482 allele at the PPARGC1A locus is lower in World-class Spanish male endurance athletes (cases)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.