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Article

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2007

Liberman Ana C, Refojo Damian, Druker Jimena, Toscano Marta, Rein Theo, Holsboer Florian, Arzt Eduardo

Abstract excerpt

Glucocorticoids (GCs) immunosuppression acts via regulation of several transcription factors (TF), including activating protein (AP)-1, NF-kappaB, and NFAT. GCs inhibit Th1 cytokines and promote a shift toward Th2 differentiation. Th1 phenotype depends on TF T-bet. In this study, we examined GC regulation of T-bet. We found that GCs inhibit T-bet transcriptional activity. We show that glucocorticoid receptor (GR)...

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Source

Identifiers

PMID: 17215482
DOI: 10.1096/fj.06-7452com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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