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Article

The YMDD and rtA194T mutations result in decreased replication capacity in wild-type HBV as well as in HBV with precore and basal core promoter mutations.

Antiviral chemistry & chemotherapy - 23 Aug 2011

Zhu Yuao, Curtis Maria, Borroto-Esoda Katyna

Abstract excerpt

BACKGROUND: A recent study indicated that addition of the hepatitis B e antigen (HBeAg) precore (PC) or basal core promoter (BCP) mutations to wild-type HBV offset the reduced replication of the HBV polymerase rtA194T±rtL180M+rtM204V mutations. rtA194T was reportedly associated with tenofovir resistance. We investigated these findings in genotype D HBV, where both PC and BCP naturally occur in vivo. METHODS: A...

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PMID: 21860069
DOI: 10.3851/IMP1791

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