Article
Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene.
Virology - 20 Jul 2002
Torresi Joseph, Earnest-Silveira Linda, Civitico Gilda, Walters Tomos E, Lewin Sharon R, Fyfe Janet, Locarnini Stephen A, Manns Michael, Trautwein Christian, Bock Thomas C
Abstract excerpt
The introduction of lamivudine (LMV) for the treatment of chronic hepatitis B infection has been an important advance in the management of this disease. However, the long-term efficacy of LMV may become limited by the emergence of antiviral-resistant hepatitis B virus (HBV) mutants. The two most common LMV-resistant mutants produce changes in the viral polymerase protein (rt) of rtM204I and rtL180M/M204V...
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