Article
The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains.
Hepatology (Baltimore, Md.) - 1 Apr 2009
Amini-Bavil-Olyaee Samad, Herbers Ulf, Sheldon Julie, Luedde Tom, Trautwein Christian, Tacke Frank
Abstract excerpt
UNLABELLED: Tenofovir is a new effective treatment option for patients with chronic hepatitis B, but could be potentially hampered by mutations in the hepatitis B virus (HBV) polymerase conferring drug resistance. Drug resistance may occur preferentially if long-term administration is required, for example, in patients with hepatitis B e antigen (HBeAg)-negative HBV infection bearing precore (PC) and basal core...
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