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Article

Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.

The Journal of infectious diseases - 15 Oct 2008

Ohkawa Kazuyoshi, Takehara Tetsuo, Kato Michio, Deguchi Matsuo, Kagita Masanori, Hikita Hayato, Sasakawa Akira, Kohga Keisuke, Uemura Akio, Sakamori Ryotaro, Yamaguchi Shinjiro, Miyagi Takuya, Ishida Hisashi, Tatsumi Tomohide, Hayashi Norio

Abstract excerpt

BACKGROUND: Hepatitis B virus (HBV) establishes lamivudine resistance via the resistance-causative rtM204V/I mutation and the replication-compensatory rtL180M mutation. However, both lamivudine-resistant viruses with and those without rtL180M can exist in clinical settings. To elucidate the differences between viruses with and those without rtL180M, we conducted full-length sequencing analysis of HBV derived from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18713056
DOI: 10.1086/591941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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