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Article

Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2.

The Journal of biological chemistry - 6 Apr 2007

Wang Qing, Wei Xiaochao, Zhu Tianhui, Zhang Ming, Shen Run, Xing Lianping, O'Keefe Regis J, Chen Di

Abstract excerpt

BMP-2 plays an essential role in osteoblast and chondrocyte differentiation, but its signaling mechanism has not been fully defined. In the present studies, we investigated the mechanism through which BMP-2 activates the Smad6 gene. A -2006/+45 Smad6 promoter-luciferase construct was generated along with deletions and Runx2 binding site mutations to examine the role of Smad1 and Runx2 signaling following BMP-2...

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Source

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Identifiers

PMID: 17215250
DOI: 10.1074/jbc.M610997200
PMCID: PMC2636961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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