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Article

The miR-665/SOST Axis Regulates the Phenotypes of Bone Marrow Mesenchymal Stem Cells and Osteoporotic Symptoms in Female Mice.

The American journal of pathology - 1 Nov 2024

Zeng Xingxing, Yuan Xianyu, Liao Hongchun, Wei Yongfang, Wu Qinxuan, Zhu Xi, Li Qingqing, Chen Shijie, Hu Minghua

Abstract excerpt

Osteoporosis is a common degenerative skeletal disease among older people, especially postmenopausal women. Bone marrow mesenchymal stem cells (BMSCs), the progenitors of osteoblasts, are essential to the pathophysiology of osteoporosis. Herein, targeting miRNAs with differential expression in dysfunctional BMSCs was accomplished by bioinformatics analysis based on public databases. Target mRNAs were predicted...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39461772
DOI: 10.1016/j.ajpath.2024.07.022

Genes

SOST

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