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Article

Quantitative analysis of HBV cccDNA from clinical specimens: correlation with clinical and virological response during antiviral therapy.

Journal of viral hepatitis - 1 Jan 2007

Bourne E J, Dienstag J L, Lopez V A, Sander T J, Longlet J M, Hall J G, Kwiatkowski R W, Wright T, Lai C L, Condreay L D

Abstract excerpt

Attempts to investigate changes in various forms of intrahepatic hepatitis B virus (HBV) DNA during antiviral therapy have been hampered by limitations in technologies and scarcity of adequate tissue for analysis. We used a sensitive, specific assay to detect and quantitate covalently closed circular DNA (cccDNA) from total intrahepatic HBV DNA in clinical liver specimens. Total HBV DNA and cccDNA from 21...

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Identifiers

PMID: 17212645
DOI: 10.1111/j.1365-2893.2006.00775.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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