Article
Rapid Turnover of Hepatitis B Virus Covalently Closed Circular DNA Indicated by Monitoring Emergence and Reversion of Signature-Mutation in Treated Chronic Hepatitis B Patients.
Hepatology (Baltimore, Md.) - 1 Jan 2021
Huang Qi, Zhou Bin, Cai Dawei, Zong Yuhua, Wu Yaobo, Liu Shi, Mercier Alexandre, Guo Haitao, Hou Jinlin, Colonno Richard, Sun Jian
Abstract excerpt
BACKGROUND AND AIMS: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) plays a pivotal role in the establishment and persistence of HBV infection. Understanding the turnover time of preexisting cccDNA pools would be helpful in designing strategies to clear HBV by fully blocking the de novo generation of cccDNA. APPROACH AND RESULTS: In this study, we retrospectively monitored the emergence and...
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