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Article

Antiviral therapy of chronic hepatitis B: can we clear the virus and prevent drug resistance?

Antiviral chemistry & chemotherapy - 1 Nov 2004

Zoulim Fabien

Abstract excerpt

Antiviral therapy of chronic HBV infection remains a clinical challenge. Once this infection has been-established, the viral genome persists for life, either as an integrated genome or as episomal covalently closed circular DNA (cccDNA). The latter is the source of renewed viral replication in case of immune depression or after antiviral drug withdrawal. The mechanisms of clearance of infected cells involve CD8+...

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Share to CD8-Positive T-Lymphocytes
Share to DNA, Circular
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Therapy, Combination

Share to Enzyme Inhibitors

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Killer Cells, Natural

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Identifiers

PMID: 15646643
DOI: 10.1177/095632020401500602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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