Article
The electrogenic sodium bicarbonate cotransporter: developmental expression in rat brain and possible role in acid vulnerability.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 2000
Giffard R G, Papadopoulos M C, van Hooft J A, Xu L, Giuffrida R, Monyer H
Abstract excerpt
The electrogenic sodium bicarbonate cotransporter (NBC) is expressed in glial cells in the brain and plays an important role in the regulation of both intracellular and extracellular pH. Differential vulnerability to acidosis between neurons and glia has been noted and may contribute to infarction after cerebral ischemia. Ionic substitution studies and inhibition of injury by 4,...
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