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Article

Biochemical and structural brain alterations in female mice with cerebral pyruvate dehydrogenase deficiency.

Journal of neurochemistry - 1 Dec 2004

Pliss Lioudmila, Pentney Roberta J, Johnson Mark T, Patel Mulchand S

Abstract excerpt

Pyruvate dehydrogenase complex (PDC) deficiency is an inborn metabolic disorder associated with a variety of neurologic abnormalities. This report describes the development and initial characterization of a novel murine model system in which PDC deficiency has been introduced specifically into the developing nervous system. The absence of liveborn male and a roughly 50% reduction in female offspring following...

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Identifiers

PMID: 15569252
DOI: 10.1111/j.1471-4159.2004.02790.x

Genes

PDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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