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Article

A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Mar 2005

David Sean P, Murthy Naga Venkatesha, Rabiner Eugenii A, Munafó Marcus R, Johnstone Elaine C, Jacob Robyn, Walton Robert T, Grasby Paul M

Abstract excerpt

In humans, 5-HT1A receptors are implicated in anxiety and depressive disorders and their treatment. However, the physiological and genetic factors controlling 5-HT1A receptor expression are undetermined in health and disease. In this study, the influence of two genetic factors on 5-HT1A receptor expression in the living human brain was assessed using the 5-HT1A-selective positron emission tomography (PET) ligand...

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Identifiers

PMID: 15758168
DOI: 10.1523/JNEUROSCI.3769-04.2005
PMCID: PMC1942077

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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