Article
Mutation in mexR-gene leading to drug resistance in corneal keratitis in human.
Indian journal of experimental biology - 1 Nov 2006
Suman G, Khan M, Sabitha K, Jamil Kaiser
Abstract excerpt
The present study deals with the genetic polymorphism of the mexR gene which is involved in the resistance to drugs like ciprofloxacin. Mutations in mexR result in increased resistance to multiple antibiotics due to overexpression of this efflux system. The MexR product contains 147 amino acids with a molecular mass of 16,964 Da. We detected 28 point mutations in 14 samples from corneal scraping infected with...
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