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Article

Critical biophysical properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance.

Protein science : a publication of the Protein Society - 1 Apr 2010

Andrésen Cecilia, Jalal Shah, Aili Daniel, Wang Yi, Islam Sohidul, Jarl Anngelica, Liedberg Bo, Wretlind Bengt, Mårtensson Lars-Göran, Sunnerhagen Maria

Abstract excerpt

The self-assembling MexA-MexB-OprM efflux pump system, encoded by the mexO operon, contributes to facile resistance of Pseudomonas aeruginosa by actively extruding multiple antimicrobials. MexR negatively regulates the mexO operon, comprising two adjacent MexR binding sites, and is as such highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20095047
DOI: 10.1002/pro.343
PMCID: PMC2867009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20095047-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Critical biophysical properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance.PMID 20095047Read ↗

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