Mutations of brainstem transcription factors and central respiratory disorders.

doi:10.1016/j.molmed.2004.11.005

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Article

Mutations of brainstem transcription factors and central respiratory disorders.

Trends in molecular medicine - 1 Jan 2005

Blanchi Bruno, Sieweke Michael H

Abstract excerpt

Several pathologies, such as central hypoventilation syndrome, central sleep apnea and cases of sudden infant death syndrome, involve defects in central breathing control. On a cellular and molecular level these disorders remain poorly defined and mechanistically not understood. A complex network of distinct brainstem neurons coordinates respiratory rhythm generation and modulation, which traditionally has been...

Topics

Animals
Brain Stem
Cell Differentiation
Humans
Mice
Mice, Knockout
Mutation
Neurons
Respiration
Respiration Disorders
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 15649819
DOI: 10.1016/j.molmed.2004.11.005

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