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Article

Effect of reparation of repeat sequences in the human alpha-synuclein on fibrillation ability.

International journal of biological sciences - 2 Oct 2006

Sode Koji, Ochiai Sayaka, Kobayashi Natsuki, Usuzaka Eri

Abstract excerpt

The aggregation and fibrillation of alpha-synuclein has been implicated as a causative factor in the Parkinson's disease. The hexamer motif KTKEGV is found in each of the seven imperfect repeat sequences in the N-terminal half of alpha-synuclein. The motif is not fully conserved in the sixth and seventh repeats. We created mutants in which the motif was repaired to be fully conserved in either (Rep6 and Rep7) or...

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Identifiers

PMID: 17200685
DOI: 10.7150/ijbs.3.1
PMCID: PMC1622890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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