Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity.

doi:10.2337/db16-0522

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Article

Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity.

Diabetes - 1 Oct 2016

Jiao Hong, Kulyté Agné, Näslund Erik, Thorell Anders, Gerdhem Paul, Kere Juha, Arner Peter, Dahlman Ingrid

Abstract excerpt

Identification of rare sequencing variants with a larger functional impact has the potential to highlight new pathways contributing to obesity. Using whole-exome sequencing followed by genotyping, we have identified a low-frequency coding variant rs2076349 (V527M) in the laminin subunit β3 (LAMB3) gene showing strong association with morbid obesity and thereby risk of type 2 diabetes. We exome-sequenced 200...

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PMID: 27431458
DOI: 10.2337/db16-0522

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LAMB3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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