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Article

No correlation between BRAF<sup>V600E</sup> mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan

16 Sept 2005

Abstract excerpt

OBJECTIVE: Genetic alterations in four oncogenes, namely RAS point mutations, RET rearrangements (RET/PTC), NTRK1 rearrangements (TRK) and BRAF point mutations have been identified in human papillary thyroid carcinomas (PTCs). These oncogenes act along the RET/PTC(TRK)-RAS-BRAF-MEK-MAPK kinase pathway, mediating a number of cellular fates including growth, proliferation and survival in thyroid cells. In this...

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PMID: 16181240
DOI: 10.1111/j.1365-2265.2005.02367.x

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