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Article

The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study.

The journal of headache and pain - 1 Apr 2006

Hagen Knut, Pettersen Elin, Stovner Lars Jacob, Skorpen Frank, Zwart John-Anker

Abstract excerpt

The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception, and one study has found that migraine was less likely among those with the Val/Val polymorphism. In the 1995-97 Nord-Trøndelag Health (HUNT) Study, the association between the Val158Met polymorphism and headache was evaluated in a random sample of 2451 individuals. No...

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Identifiers

PMID: 16688411
DOI: 10.1007/s10194-006-0281-7
PMCID: PMC3451703

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study.PMID 16688411Read ↗

No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study.Semantic proximity Read ↗

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High systolic blood pressure is associated with Val/Val genotype in the catechol-o-methyltransferase gene. The Nord-Trøndelag Health Study (HUNT).Semantic proximity Read ↗

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The association between COMT Val158Met polymorphism and migraine risk: A meta-analysis.Semantic proximity Read ↗

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Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type HeadacheSemantic proximity Read ↗

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