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Article

Reversible Inhibition of Mitochondrial Protein Synthesis during Linezolid-Related Hyperlactatemia

29 Dec 2006

Abstract excerpt

The objective of the present study was to determine the mitochondrial toxicity mechanisms of linezolid-related hyperlactatemia. Five patients on a long-term schedule of linezolid treatment were studied during the acute phase of hyperlactatemia and after clinical recovery and lactate normalization following linezolid withdrawal. Mitochondrial studies were performed with peripheral blood mononuclear cells and...

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Identifiers

PMID: 17194826
DOI: 10.1128/aac.01190-06

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