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Article

Mitochondrial Toxicity Associated with Linezolid

23 Nov 2005

Abstract excerpt

To the Editor: Linezolid belongs to a family of antimicrobial agents (oxazolidinones) that inhibit bacterial protein synthesis by preventing the fusion of 30S and 50S ribosomal subunits.1 Hyperlactatemia, metabolic acidosis, and peripheral neuropathy are adverse effects of linezolid,2,3 which could be related to the drug's capacity for interference with mitochondrial function.4 We studied mitochondria from three...

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PMID: 16306535
DOI: 10.1056/nejm200511243532123

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