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Could mitochondrial DNA quantitation be a surrogate marker for drug mitochondrial toxicity?

AIDS reviews - 1 Jan 2000

de Mendoza Carmen, Sanchez-Conde Matilde, Ribera Esteve, Domingo Pere, Soriano Vincent

Abstract excerpt

Nucleoside reverse transcriptase inhibitors have been proven to inhibit mitochondrial DNA (mtDNA) polymerase gamma, resulting in decreased mtDNA synthesis and consequential risk for the development of mitochondrial dysfunction in HIV-infected individuals. The depletion of mtDNA seems to correlate with the development of symptomatic hyperlactatemia and lipoatrophy. A validated quantitative mitochondrial DNA assay...

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PMID: 15595434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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