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Article

Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis.

EBioMedicine - 1 Nov 2015

Song Taeksun, Lee Myungsun, Jeon Han-Seung, Park Yumi, Dodd Lori E, Dartois Véronique, Follman Dean, Wang Jing, Cai Ying, Goldfeder Lisa C, Olivier Kenneth N, Xie Yingda, Via Laura E, Cho Sang Nae, Barry Clifton E, Chen Ray Y

Abstract excerpt

Long-term linezolid use is limited by mitochondrial toxicity-associated adverse events (AEs). Within a prospective, randomized controlled trial of linezolid to treat chronic extensively drug-resistant tuberculosis, we serially monitored the translational competence of mitochondria isolated from peripheral blood of participants by determining the cytochrome c oxidase/citrate synthase activity ratio. We compared...

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Identifiers

PMID: 26870788
DOI: 10.1016/j.ebiom.2015.09.051
PMCID: PMC4740314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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