Article
Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jun 2005
Palenzuela Lluis, Hahn Noah M, Nelson Robert P, Arno Janet N, Schobert Carol, Bethel Robert, Ostrowski Lisa A, Sharma Manjuli R, Datta Partha P, Agrawal Rajendra K, Schwartz Jennifer E, Hirano Michio
Abstract excerpt
Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.
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