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Article

Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism.

Antimicrobial agents and chemotherapy - 1 Jul 2014

Del Pozo J L, Fernández-Ros N, Sáez E, Herrero J I, Yuste J R, Banales J M

Abstract excerpt

Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.

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Share to Acetamides
Share to Acidosis, Lactic
Share to Linezolid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Transplantation

Share to Mitochondria

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Share to RNA, Ribosomal, 16S

Share to Tuberculosis, Pulmonary

Source

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Identifiers

PMID: 24798272
DOI: 10.1128/AAC.02856-14
PMCID: PMC4068560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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