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Article

Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Mar 2008

Reeve Simon P, Lin Xinda, Sahin Bahar H, Jiang Fangfang, Yao Aiyu, Liu Zhihua, Zhi Hui, Broadie Kendal, Li Wei, Giangrande Angela, Hassan Bassem A, Zhang Yong Q

Abstract excerpt

Fragile X syndrome is the most common form of heritable mental retardation caused by the loss of function of the fragile X mental retardation protein FMRP. FMRP is a multidomain, RNA-binding protein involved in RNA transport and/or translational regulation. However, the binding specificity between FMRP and its various partners including interacting proteins and mRNA targets is essentially unknown. Previous work...

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Identifiers

PMID: 18354025
DOI: 10.1523/JNEUROSCI.5528-07.2008
PMCID: PMC6670702

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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