Article

The KH domains of FMRP differentially regulate neuronal granule formation, dynamics, and function in <i>Drosophila</i>

2021-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Fragile X Syndrome (FXS) is the most prevalent cause of inherited mental deficiency and is the most common monogenetic cause of autism spectral disorder (ASD). Here, we demonstrate that disease-causing missense mutations in the conserved K homology (KH) RNA binding domains (RBDs) of FMRP cause defects in its ability to form RNA transport granules in neurons. Using molecular, genetic, and imaging...

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Literature Corpus work: 5b26ed70-793b-5fc7-8237-b76d39961850
DOI: 10.1101/2021.06.01.446613

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