Article
Influence of epidermal growth factor receptor (EGFR) gene mutations on the expression of EGFR, phosphoryl-Akt, and phosphoryl-MAPK, and on the prognosis of patients with non-small cell lung cancer.
Journal of surgical oncology - 1 Jan 2007
Sonobe Makoto, Nakagawa Masatsugu, Takenaka Kazumasa, Katakura Hiromichi, Adachi Masashi, Yanagihara Kazuhiro, Otake Yosuke, Wada Hiromi, Tanaka Fumihiro
Abstract excerpt
BACKGROUND AND OBJECTIVES: In this paper we examined the influence of epidermal growth factor receptor (EGFR) gene mutations on EGFR expression, downstream mediators, and survival in patients with non-small cell lung cancer (NSCLC). METHODS: We retrospectively analyzed the tumors of 53 patients with completely resected pathological stage I-IIIA NSCLC for the presence of EGFR gene mutations, the expression of EGFR...
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