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Article

ERK phosphorylation as a marker of RAS activity and its prognostic value in non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2020

Reissig Timm M, Sara Linda, Ting Saskia, Reis Henning, Metzenmacher Martin, Eberhardt Wilfried E E, Zaun Gregor, Herold Thomas, Aigner Clemens, Darwiche Kaid, Stuschke Martin, Schildhaus Hans-Ulrich, Schuler Martin, Wiesweg Marcel

Abstract excerpt

BACKGROUND: Deregulated signal transduction pathways play a key role in development, progression and therapeutic resistance of non-small cell lung cancers (NSCLC). The purpose of this study is to assess the downstream markers of two well-characterized pathways and to correlate them with clinical outcome. DESIGN: 670 patients with metastatic NSCLC were prospectively enrolled in a comprehensive biomarker profiling...

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PMID: 32947221
DOI: 10.1016/j.lungcan.2020.09.005

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