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Article

Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer.

Cancer biology & therapy - 1 Jan 2011

Tanaka Yoshimichi, Terai Yoshito, Tanabe Akiko, Sasaki Hiroshi, Sekijima Tatsuharu, Fujiwara Satoe, Yamashita Yoshiki, Kanemura Masanori, Ueda Masatsugu, Sugita Michio, Franklin Wilbur A, Ohmichi Masahide

Abstract excerpt

OBJECTIVES: We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. STUDY DESIGN: EGFR mutation status was analyzed by direct sequencing in 102 Japanese ovarian cancer patients. The EGFR expression, phosphorylated Akt (pAkt), and phosphorylated ERK (pERK)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21057220
DOI: 10.4161/cbt.11.1.13877
PMCID: PMC3047101

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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