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Article

Diversity of epidermal growth factor receptor-mediated activation of downstream molecules in human lung carcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2006

Suzuki Shioto, Igarashi Satoshi, Hanawa Mitsuhiko, Matsubara Hirochika, Ooi Akishi, Dobashi Yoh

Abstract excerpt

The correlations among epidermal growth factor receptor (EGFR) gene amplification, gene mutation, overexpression/phosphorylation of EGFR protein and activation of its downstream molecules, signal transducers and activators of transcription 3 (Stat-3), Akt and extracellular signal-related protein kinase 1/2 (Erk1/2) were investigated in 28 cases of human lung carcinomas. In five cases of carcinomas with EGFR...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

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Share to Proto-Oncogene Proteins c-akt

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Source

Identifiers

PMID: 16648865
DOI: 10.1038/modpathol.3800619

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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