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Article

Segmental differences in Slc26a3-dependent Cl- absorption and HCO3- secretion in the mouse large intestine in vitro in Ussing chambers.

The journal of physiological sciences : JPS - 29 Jan 2021

Hayashi Hisayoshi, Nagai Hiroki, Ohba Kou-Ichiro, Soleimani Manoocher, Suzuki Yuichi

Abstract excerpt

The anion exchanger slc26a3 (DRA), which is mutated in congenital chloride-losing diarrhea, is expressed in the apical membrane of the cecum and middle-distal colon but not in the proximal colon of rodent large intestines. To elucidate the functional roles of DRA, we measured unidirectional 36Cl- and 22Na+ fluxes and HCO3- secretion in vitro in each of these segments using DRA-KO mice. Robust Cl- absorption,...

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Identifiers

PMID: 33514305
DOI: 10.1186/s12576-020-00784-9
PMCID: PMC10717946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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