Article
Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting.
BMC microbiology - 15 Oct 2009
Noranate Nitchakarn, Prugnolle Franck, Jouin Hélène, Tall Adama, Marrama Laurence, Sokhna Cheikh, Ekala Marie-Thérèse, Guillotte Micheline, Bischoff Emmanuel, Bouchier Christiane, Patarapotikul Jintana, Ohashi Jun, Trape Jean-François, Rogier Christophe, Mercereau-Puijalon Odile
Abstract excerpt
BACKGROUND: Genetic evidence for diversifying selection identified the Merozoite Surface Protein1 block2 (PfMSP1 block2) as a putative target of protective immunity against Plasmodium falciparum. The locus displays three family types and one recombinant type, each with multiple allelic forms differing by single nucleotide polymorphism as well as sequence, copy number and arrangement variation of three amino acid...
Topics
- Adolescent
- Adult
- Alleles
- Animals
- Antibodies, Protozoan
- Child
- Child, Preschool
- DNA, Protozoan
- Follow-Up Studies
- Gene Frequency