Article
Structural and mechanistic insights into the interaction between Rho and mammalian Dia.
Nature - 26 May 2005
Rose R, Weyand M, Lammers M, Ishizaki T, Ahmadian M R, Wittinghofer A
Abstract excerpt
Formins are involved in a variety of cellular processes that require the remodelling of the cytoskeleton. They contain formin homology domains FH1 and FH2, which initiate actin assembly. The Diaphanous-related formins form a subgroup that is characterized by an amino-terminal Rho GTPase-binding domain (GBD) and an FH3 domain, which bind somehow to the carboxy-terminal Diaphanous autoregulatory domain (DAD) to...
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