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Article

Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase.

The Journal of biological chemistry - 14 Aug 2009

Kawasaki Yoshihiro, Tsuji Shinnosuke, Sagara Masaki, Echizen Kanae, Shibata Yoko, Akiyama Tetsu

Abstract excerpt

Mutations of the tumor suppressor adenomatous polyposis coli (APC) are responsible for sporadic and familial colorectal tumors. APC negatively regulates Wnt signaling by inducing beta-catenin degradation. It has also been shown that APC plays a role in the organization of cytoskeletal networks. APC interacts with Asef and Asef2, Rac1- and Cdc42-specific guanine nucleotide exchange factors (GEFs), and stimulates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19525225
DOI: 10.1074/jbc.M109.020768
PMCID: PMC2755965

Genes

APC
HGF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase.PMID 19525225Read ↗

Mutated APC and Asef are involved in the migration of colorectal tumour cells.Semantic proximity Read ↗

Asef, a Link Between the Tumor Suppressor APC and G-Protein SignalingSemantic proximity Read ↗

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Wnt signalling and the actin cytoskeleton.Semantic proximity Read ↗

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.Semantic proximity Read ↗

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis.Semantic proximity Read ↗

GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 CellsSemantic proximity Read ↗

Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover.Semantic proximity Read ↗

Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism.Semantic proximity Read ↗

Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.Semantic proximity Read ↗

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