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Article

Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.

Oncogene - 6 Dec 2007

Kawasaki Y, Sagara M, Shibata Y, Shirouzu M, Yokoyama S, Akiyama T

Abstract excerpt

The tumor suppressor adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumors. APC interacts with the Rac1-specific guanine-nucleotide exchange factor (GEF) Asef, which contains an APC-binding region (ABR) in addition to Dbl homology (DH), Pleckstrin (PH) and Src hom...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17599059
DOI: 10.1038/sj.onc.1210574

Genes

APC
ABR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17599059-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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