Article
HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease.
Scandinavian journal of gastroenterology - 1 Jan 2007
Jores Rita-Désirée, Frau Fulvia, Cucca Francesco, Grazia Clemente Maria, Orrù Sandra, Rais Marco, De Virgiliis Stefano, Congia Mauro
Abstract excerpt
OBJECTIVE: Celiac disease (CD) is a T-lymphocyte-mediated small intestinal enteropathy triggered and maintained by dietary gluten, with a strong genetic component mapping to the HLA genes encoding for the class II DQ(alpha1*0501, beta1*02) molecule. Damage of the small intestine may cause a variety of clinical signs ranging from isolated long-standing iron-deficiency anemia refractory to iron supplementation to...
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