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Article

Pharmacogenetics and polymorphism of human P-450 which activates and detoxicates xenobiotics and carcinogens.

Princess Takamatsu symposia - 1 Jan 1990

Kato R, Yamazoe Y, Yasumori T

Abstract excerpt

Stereoselective hydroxylation of mephenytoin is expressed polymorphically in the Japanese population: the occurrence of the poor metabolizer was approximately 20% in Japanese, which was 5 to 8 times higher than that in Caucasians. Microsomal 4'-hydroxylation of S-mephenytoin, but not of R-mephenytoin, was correlated to the content of cytochrome P-450 human-2. P-450 human-2 cDNA was cloned and expressed in yeast...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 2134689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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