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Article

Pharmacogenetics and polymorphism of human P-450 which activates and detoxicates xenobiotics and carcinogens.

Princess Takamatsu symposia - 1 Jan 1990

Kato R, Yamazoe Y, Yasumori T

Abstract excerpt

Stereoselective hydroxylation of mephenytoin is expressed polymorphically in the Japanese population: the occurrence of the poor metabolizer was approximately 20% in Japanese, which was 5 to 8 times higher than that in Caucasians. Microsomal 4'-hydroxylation of S-mephenytoin, but not of R-mephenytoin, was correlated to the content of cytochrome P-450 human-2. P-450 human-2 cDNA was cloned and expressed in yeast...

Topics

Aryl Hydrocarbon Hydroxylases
Benzo(a)pyrene
Carcinogens
Cyclophosphamide
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Hexobarbital
Humans
Japan
Microsomes, Liver
Mixed Function Oxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Genetic

Transformation, Genetic

Xenobiotics

Yeasts

Source

Identifiers

PMID: 2134689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2134689-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Pharmacogenetics and polymorphism of human P-450 which activates and detoxicates xenobiotics and carcinogens.PMID 2134689Read ↗

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Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese.Semantic proximity Read ↗

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